Therapeutic Role of Coenzyme Q10 in Male Infertility: A Semen Analysis-Based Study

Abstract

The health issue of male infertility affects about 15% of couples throughout the world and male factors drive approximately half of these cases. Sperm quality stands as a fundamental target in male infertility treatment since Ooxidative stress acts as a primary factor that impacts sperm quality. The natural compound Coenzyme Q10 (CoQ10) functions as a powerful antioxidant while serving important roles in mitochondrial bioenergetics because of its presence in semen. Measurable concentrations of CoQ10 exist in human semen with a direct relationship to enhanced sperm parameters regarded as motility as well as concentration alongside morphology. This study examines the potential of CoQ10 supplementation to enhance male fertility by improving semen quality and moderate Oxidative Stress. Clinical evidence demonstrates that CoQ10 improves sperm motility and reduces oxidative damage, thereby decreasing sperm DNA fragmentation. Research supports the use of CoQ10 supplements to enhance pregnancy achievements in assisted reproductive technology programs like in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Despite these advancements, further research is necessary to establish standardized dosages and supplementation protocols for specific infertility cases. This study not only highlights the therapeutic potential of CoQ10, but also highlights the need for additional research to fully understand its role in treating male infertility