Relationship Between Pseudomonas aeruginosa Infection and Some Physiological Parameter in Patients with UTIs
Keywords:
Pseudomonas aeruginosa, Urinary tract infections, UTI patients, Physiological parameters, Bacteria, Clinical Microbiology, Inflammation markersAbstract
The study started in November 2023 and ended in March 2024. The study concentrates on the relationship between urinary tract infections caused by Pseudomonas aeruginosa and some biochemical criteria (triglycerides, cholesterol, liver enzymes). A total of 110 blood samples were collected from patients at Al-Qurna General Hospital in Basra province to diagnose the bacterial species causing the infection and isolating the pseudomonas aeroginosa bacteria, which is one of the most common types of urinary tract infections. Triglyceride level (TG) showed a significant decrease (P˂ 0.01) in UTI-P. aeruginosa patients (99.4±6.31: 90.43 ± 8.85 mg/dl) compared to the control group (148.65 ± 6.64 mg/dl). Cholesterol concentration also recorded a significant decrease (P˂ 0.01) in UTI-P. aeruginosa (113.52 ± 6.03: 119.41 ± 8.5 mg/dl) compared to the control group (148.65 ± 6.64: 162.91 ± 5.14 mg/dl). AST of UTI-P. aeruginosa patients rise (P<0.01) (25.12 ± 1.68: 37.52 ± 3.12 U/L) compared to the control group (13.84 ± 2.17: 11.84 ± 2.51 U/L). ALT enzyme level of UTI-P. aeruginosa patients recorded higher (P˂ 0.01) value (38.15 ± 2.58: 41.57 ± 3.15 U/L) compared to the control group (16.28 ± 1.82: 13.4 ± 1.37 U/L). As well as ALP enzyme level of UTI-P. aeruginosa patients showed similar trend (82.45 ± 3.15: 92.11 ± 5.62 U/L) in comparison with the control group (57.02 ± 2.14: 51.42 ± 5.19 U/L).
Triglyceride results (TG) showed a moral decrease (P˂ 0.01) in patients with mg/dl (6.31 ± 99.4: 8.85 ± 90.43) compared to the control group recorded (± 6.64 148.65) mg/dl
Cholesterol concentration also recorded a moral decrease (P˂ 0.01) in patients where it reached
(113.52 ± 6.03: 119.41 ± 8.5) mg/dl) compared to the control group recorded (148.65 ± 6.64: 162.91 ± 5.14). Liver enzymes recorded a moral rise in AST. (P˂ 0.01) in patients at 25.12 ± 1.68: 37.52 ± 3.12 (U/L) compared to the control group recorded (13.84 ± 2.17: 11.84 ± 2.51) U/L
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M. Colella, S. Topi, R. Palmirotta, D. D’Agostino, I. A. Charitos, R. Lovero, and L. Santacroce, "An overview of the microbiota of the human urinary tract in health and disease: Current issues and perspectives," Life, vol. 13, no. 7, p. 1486, Jul. 2023. DOI: https://doi.org/10.3390/life13071486.
A. S. Graseck, J. L. Thompson, A. S. Bryant, A. G. Cahill, N. S. Silverman, and M. A. Turrentine, "Urinary tract infections in pregnant individuals," Obstet. Gynecol., Aug. 2023. Available: https://www.acog.org/clinical/clinical-guidance/clinical-consensus/articles/2023/08/urinary-tract-infections-in-pregnant-individuals.
A. E. Anas et al., "Prevalence and associated risk factors of urinary tract infection among diabetic patients: A cross-sectional study," Healthcare, vol. 11, no. 6, p. 861, Mar. 2023. DOI: https://doi.org/10.3390/healthcare11060861.
S. P. Diggle and M. Whiteley, "Pseudomonas aeruginosa: Opportunistic pathogen and lab rat," Microbiology (Reading), vol. 166, no. 1, pp. 30–33, Jan. 2020. DOI: https://doi.org/10.1099/mic.0.000860.
H. Ayesha et al., "Biofilm formation and antibiotic resistance in Pseudomonas aeruginosa," The Microbe, vol. 3, p. 100078, 2024. DOI: https://doi.org/10.1016/j.micbio.2024.100078.
M. Ghazala, R. Md Tabish, S. Moayad, and A. Mohammad, "Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review," Pharmaceuticals (Basel), vol. 16, no. 11, p. 1615, Nov. 2023. DOI: https://doi.org/10.3390/ph16111615.
S. J. Wood, T. M. Kuzel, and S. H. Shafikhani, "Pseudomonas aeruginosa: Infections, animal modeling, and therapeutics," Cells, vol. 12, no. 1, p. 199, Jan. 2023. DOI: https://doi.org/10.3390/cells12010199.
L. Khoury, Z. Schnapp, and M. Konopnicki, "Improving management: Novel guidelines for diagnosing urinary tract infection in infants," Pediatr. Infect. Dis. J., 2024. DOI: https://doi.org/10.1097/inf.0000000000004292.
J. E. S. Jürgen, F. Reinhard, and K. G. N. Kurt, "Urinary tract infections in patients with renal insufficiency and dialysis: Epidemiology, pathogenesis, clinical symptoms, diagnosis and treatment," GMS Infect. Dis., vol. 9, Doc07, 2021. DOI: https://doi.org/10.3205/id000076.
J. B. Michael and W. L. Stephen, "Uncomplicated urinary tract infections," Feb. 21, 2025. Available: https://www.ncbi.nlm.nih.gov/books/NBK470347.
M. Goss-Sampson, Statistical Analysis in JASP: A Guide for Students, 2022. Available: https://www.researchgate.net/publication/370472206_Statistical_Analysis_in_JASP_-_A_Students_Guide_v161.
S. Ayan and W. L. Stephen, "Complicated urinary tract infections," Dec. 7, 2024. Available: https://www.ncbi.nlm.nih.gov/books/NBK537137.
S. A. Ahmed, Molecular Detection of Some Virulence Genes in Pseudomonas aeruginosa Isolated from Clinical Source, M.S. thesis, Near East Univ., 2021. Available: https://docs.neu.edu.tr/library/9299808495.pdf.
K. Tishkowski and V. Gupta, "Erythrocyte sedimentation rate," in StatPearls. Treasure Island, FL: StatPearls Publishing, 2023. Available: https://www.ncbi.nlm.nih.gov/books/NBK557485/.
A. Dwaya, A. Urayet, M. B. Milad, and A. M. Alkout, "Platelet count as useful indicator for gram-type of bacteria causing urinary tract infection in women," Iberoam. J. Med., vol. 4, no. 1, pp. 24–29, 2022. DOI: https://doi.org/10.53986/ibjm.2022.0006.
J. Dominik, K. Stefan, and N. Axel, "Sepsis—Pathophysiology and therapeutic concepts," Front. Med. (Lausanne), vol. 8, p. 628302, 2021. DOI: https://doi.org/10.3389/fmed.2021.628302.
L. V. de Souza, A. Hoffmann, and G. Weiss, "Impact of bacterial infections on erythropoiesis," Expert Rev. Anti Infect. Ther., vol. 19, no. 5, pp. 619–633, 2021. DOI: https://doi.org/10.1080/14787210.2021.1841636.
K. Kenneth and K. R. Feingold, "The effect of inflammation and infection on lipids and lipoproteins," in Endotext, K. R. Feingold et al., Eds. South Dartmouth, MA: MDText.com, Inc., 2000. Available: https://www.ncbi.nlm.nih.gov/books/NBK326741/.
W. Khovidhunkit, M. S. Kim, R. A. Memon, J. K. Shigenaga, A. H. Moser, K. R. Feingold, and C. Grunfeld, "Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host," J. Lipid Res., vol. 45, no. 7, pp. 1169–1196, Jul. 2004. DOI: https://doi.org/10.1194/jlr.r300019-jlr200
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