Estimation of some physiological biomarkers in hyperlipidemic Patient men in Al- Zubair General Hospital / Basrah province, Iraq
DOI:
https://doi.org/10.56714/bjrs.49.1.14Keywords:
Hyperlipidemia, VCAM-1, ox, LDL, MDA, GPX-1Abstract
Hyperlipidemia is a serious public health problem that affects many People in the world's, and it has been classified as one of the five causes of death in the world. As indicated by the World Health Organization (WHO), in 2030, hyperlipidemia incidence may increase the cardiovascular diseases to approximately 23.6 million people in the world. The aim of the study: Estimation of some physiological biomarkers levels in the serum of hyperlipidemic patients to predict atherosclerotic and cardiovascular disease. In addition to determine the effect of smoking and body mass index on the levels of biomarkers in hyperlipidemic patients.Patients and Methods: The study was conducted on patients who visited the internal consultation unit at Al-Zubair Hospital of Basra Health Directorate during the period from October 2020 to February 2021. The study was applied to a random sample of 60 hyperlipidemia men and 21 volunteers as a health group for comparison, whose ages range from 20-60 years. RESULTS: The results showed a significant increase in the levels of both Vascular cell adhesion molecule-1 (VCAM-1) and Malondialdehyde (MDA) and a significant decrease in the level of Glutathione Peroxidase-1 (GPX-1) in smoking patients compared to the healthy group. While Oxidized low-density lipoprotein (ox-LDL) did not show a significant difference between the patients smokers and healthy group. While the results showed a significant increase in the levels of VCAM-1, ox-LDL and MDA and a significant decrease in the level of GPX-1 among patients in the overweight and obese groups compared with the healthy group. The results did not show significant differences between the patients of the normal weight category and the healthy group.
Downloads
References
P.R. Mishra, P.K. Panda, K.C. Apanna, S. Panigrahi, Pharmacol, 3, 925 (2011).
S. Sudhakaran, T. Bottiglieri, K.M. Tecson, A.Y. Kluger, P.A. McCullough, Reviews in cardio med,19, 3,77 (2018).
S. Jain, S. L. Shapiro, S. Swanick, S.C. Roesch, P.J. Mills, I. Bell, G.E. Schwartz, Annal. of beh med 33(1),11 (2007).
K.E. Machaba, S.Z. Cobongela, R.A. Mosa, L.A. Oladipupo, T.G. Djarova, A.R. Opoku, Lipids in health and disease 13(1),1 (2014).
M.I. Alkanaani, E.R. Rajab, A.M.H. Abdulwahed, T. Dabos, B. Alshammiri, S.N. Abdullah, and M.Q. AL-Samarraie, Biochem Cell Arch 20(1),1191 (2020).
B. Nakken, G. Papp, V. Bosnes, M. Zeher, G. Nagy, P. Szodoray, Immuno letters 189,13 (2017).
L. Osborn, C. Hession, R. Tizard, C. Vassallo, S. Luhowskyj, G. Chi-Rosso, R. Lobb, Cell 59(6),1203 (1989).
G.E. Rice, M.P. Bevilacqua, Sci. 246(4935), 1303 (1989).
J.M. Cook-Mills, M.E. Marchese, H. Abdala-Valencia, Antioxi and redox signaling 15(6), 1607 (2011).
M. van Oosten, E. van de Bilt, H.E. de Vries, T.J. van Berkel, J. Kuiper, Hep, 22(5),1538 (1995).
R. Sharma, T.P. Khaket, C. Dutta, B. Chakraborty, and T.K. Mukherjee, Cell Oncolo, 40(3),199 (2017).
M. Schlesinger, and G. Bendas, Int J of Cancer 136(11),2504 (2015).
O. Barreiro, M. Yáñez-Mó, M. Sala-Valdés, M.D. Gutiérrez-López, S. Ovalle, A. Higginbottom, and F. Sánchez-Madrid, Blood 105(7), 2852 (2005).
E.P. van der Vorst, C. Weber, and M.M. Donners, J. Thromb. Haemost, 118(07), 1167 (2018).
W. Mu, M. Chen, Z. Gong, F. Zheng, and Q. Xing, Exp and thera med, 10(2), 423 (2015).
P. Marchio, S. Guerra-Ojeda, J.M. Vila, M. Aldasoro, V.M. Victor, and M.D. Mauricio, Oxid med and cell longev, 3(8),567 (2019).
B. Enkhmaa, E, Anuurad,W. Zhang,T. Tran and L. Berglund, genotype-phenotype relationship and impact on atherogenic risk, 4(6), 403 (2010).
A. Zmysłowski, and A. Szterk, Lipids in health and disease, 16(1), 1 (2017).
T. Hevonoja, M.O. Pentikäinen, M. T. Hyvönen, P.T. Kovanen, and M. Ala-Korpela, Biochi et Biophy Acta (BBA)-Mol and cell bio of lipids, 1488(3), 189 (2000).
G.C. Mills, J of Bio Che, 229(1),189 (1957).
T. Shiomi, H. Tsutsui, H. Matsusaka, K. Murakami, S. Hayashidani, M. Ikeuchi, and A. Takeshita, Circul, 109(4), 544 (2004).
S. Blankenberg, H.J. Rupprecht, C. Bickel, D. Peetz, G. Hafner,and L. Tiret, Circul, 104(12), 1336 (2001).
C. Borrás, J. Gambini, M.C. Gómez‐Cabrera, J. Sastre, F.V. Pallardó, G.E. Mann, and J. Viña, Aging cell, 4(3),113 (2005).
O. Toussaint, A. Houbion, and J. Remacle, Toxicol, 81(2),89 (1993).
H.S. Suzen, E. Gucyener, O. Sakalli, Z. Uckun, G. Kose, D. Ustel and Y. Duydu, Mol Bio Reports 37(1), 87 (2010).
Z. Singh, I.P. Karthigesu, P. Singh, and K.A.U. R. Rupinder, Iran J of Public Health, 43(3),7 (2014).
A.M. Sawant, D. Shetty, R. Mankeshwar, and T.F. Ashavaid, Japi, 56(2), 99 (2008).
F. Nouh, M. Omar, and M. Younis, Asian J of Cardio Res, 2(1),1 (2019).
A. Yurdagul Jr, F.J. Sulzmaier, X.L. Chen, C.B. Pattillo, D.D. Schlaepfer, and A.W. Orr, J. of cell sci, 129(8),1580 (2016).
R.J. Gøbel, S.M. Jensen, H. Frøkiær, C. Mølgaard, and K.F. Michaelsen, Acta paediatrica, 101(2), 192 (2012).
X. Xu, Z. Yu, L. Shuai, Y. Guo, D. Duan, and P. Fu, J of Food Biochemi, 37(2),129 (2013).
T. Lawrence, Cold Spring Harbor perspectives in bio, 1(6),651 (2009).
P. Libby, P.M. Ridker, and G.K. Hansson, Nat, 3(47), 317 (2011).
M. Adriana, A. Santoso, H.O. Hermawan, R.A. Nugraha, B.S. Pikir, and I.G.R. Suryawan, version 1; awaiting peer review (2021).
J.E. Harris , Smoking and tobacco control monograph,7,59 (1996).
R.R. Huxley, and M. Woodward, The Lancet, 378(9799), 1297 (2011).
T.M. Abdelghany, R.S. Ismail, F.A. Mansoor, J.R. Zweier, F. Lowe, and J.L. Zweier, Nitric Oxid,76,113 (2018).
A. Al-Shorman, H. Al-Domi, and A. Faqih, Swiss med weekly, 21 (2017).
K.L. Andgraf, D. Rockstroh,I.V. Wagner,S. Weise, R. Tauscher, J.T. Schwartze, and A. Körner, Diabetes, 64(4), 1249 (2015).
A. Daiber, D. Frein, D. Namgaladze, and V. Ullrich, J. of Bio Che, 277(14), 11882 (2002).
C.G. Magnussen, J. Koskinen, W. Chen, R. Thomson, M.D. Schmidt, S.R. Srinivasan, and ,O. T. Raitakari ,Circul, 122(16), 1604 (2010).
J. Olza, C.M. Aguilera, M. Gil-Campos, R. Leis, G. Bueno, M. Valle, and Á. Gil, Ann of Nut and Metabol, 66(2-3), 72 (2015).
A.V. Poznyak, N.G. Nikiforov, A.M. Markin, D.A. Kashirskikh, V.A. Myasoedova, E. V. Gerasimova, and A.N. Orekhov, Front. Pharmacol, 2248 (2021).
P.N. Durrington, B. Mackness, and M.I. Mackness, Arterioscl, throm, and vas bio, 21(4), 473. (2001).
A. Mezentsev, E. Bezsonov, D. Kashirskikh, M.S. Baig, A.H. Eid, and A. Orekhov, Biomedicines, 9(6), 600 (2021).
E.A. Ivanova, V.A. Myasoedova, A.A. Melnichenko, A.V. Grechko,and A.N.Orekhov, Oxi. med and cell longev, (2017).
T. Weinbrenner, J. Vioque, X. Barber, and L. Asensio, Gerontol, 52(5), 275 (2006).
V. Mohamed-Ali, S. Goodrick, A. Rawesh, D.R . Katz, J.M. Miles, J.S. Yudkin, and S.W. Coppack, The J. of Clin Endo and Metabol, 82(12),4196 (1997).
V. Mohamed-Ali, S. Goodrick, K. Bulmer, J.M. Holly, J.S. Yudkin, and S.W. Coppack, Amer J. of Physio-Endocrino and Metabol, 277(6), E971 (1999).
S.W. Coppack, Proceedings of the nutrit soc, 60(3), 349 (2001).
G. Davì, M.T. Guagnano, G. Ciabattoni, , S. Basili, A. Falco, M. Marinopiccoli, and C. Patrono, Jama, 288(16), 208 (2002).
S. Tangvarasittichai, Wor J of diabetes, 6(3), 456 (2015).
S.W. Coppack, R.D. Evans, R.M. Fisher, K.N. Frayn, G.F. Gibbons, S.M. Humphreys, and T.D.R. Hockaday, Metabol, 41(3),264 (1992).
J.A. Kim, M.Montagnani, K.K.Koh,and M.J. Quon, Mol and pathophysiol mech, 113(15), 1888 (2006).
S. Tangvarasittichai, P. Poonsub, and O. Tangvarasittichai, Indin J of Med Res, 131(5), 641 (2010).
R.L. Yang, Y.H. Shi, G. Hao, W. Li, and W. Le, J Clin Biochem Nutr, 43(3), 154 (2008).
M. Aikawa, S. Sugiyama, C.C. Hill, S.J.Voglic, E. Rabkin, Y. Fukumoto, and P. Libby, Circulation, 106(11), 1390 (2002).
S. Zheng, Z. Qian, L. Sheng, and N. Wen, J of cardio pharmacol,47,1,70 (2006).
T. Quéméneur, F. Martin-Nizard, A. Kandoussi, X. Kyndt, E. Hachulla, and M. Lambert, In Seminars in arthri and rheumat 37(3),149 (2007).
R. Olivero-David, A. Schultz-Moreira, M. Vázquez-Velasco, L. González-Torres, S. Bastida, J. Benedí and F.J. Sánchez-Muniz, British J of nutrit 106(10),1476 (2011).
G. Kamceva, Z. Arsova-Sarafinovska, T. Ruskovska, M. Zdravkovska, L. Kamceva-Panova, and E. Stikova, Macedonian J of med sci, 4(4), 636 (2016).
N.L. Madhikarmi, and M. Gautam, J of Heal Sci, 6(2),1481 (2021).
Y. Kamisaki, K. Wada, K. Nakamoto, Y. Kishimoto, K. Ashida, and T. Itoh, IUBMB Life, 42(1),1 (1997).
W.A. Pryor, Environ. Health Perspect., 105(4),875 (1997).
P. Puri, F. Mirshahi, O. Cheung, R. Natarajan, J.W. Maher, J.M. Kellum, and A.J. Sanyal, Gastroenterol, 134(2),568 (2008).
G. Solinas, and M. Karin, The FASEB J, 24(8), 2596 (2010).
Y. Styskal, Free Radic Biol Med , 52(1),46(2012).
M. Knaś, M. Maciejczyk, K. Sawicka, K. Hady, M. Niczyporuk, J.R. Ładny, and A. Zalewska, J of Oral Pathol and Med, 45(6), 455 (2016).
M. Valko, D. Leibfritz, J. Moncol, M.T. Cronin, M. Mazur, and J. Telser, The inter J of bioche and cell bio, 39(1),44 (2007).
K. Fejfer, P. Buczko, M. Niczyporuk, J.R. Ładny, H.R. Hady, M. Knaś, and M. Maciejczyk, Bio Med Res Inter, (2017).
S. Sfar, R. Boussoffara, M.T. Sfar, and A. Kerkeni, Nutrit J, 12(1),1 (2013).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Ahmed Zghair , Mufid Abou -Turab, Heba Yser
This work is licensed under a Creative Commons Attribution 4.0 International License.
